Evidence for Fusion Between Cardiac and Skeletal Muscle Cells

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Evidence for fusion between cardiac and skeletal muscle cells.

Cardiomyoplasty with skeletal myoblasts may benefit cardiac function after infarction. Recent reports indicate that adult stem cells can fuse with other cell types. Because myoblasts are "fusigenic" cells by nature, we hypothesized they might be particularly likely to fuse with cardiomyocytes. To test this, neonatal rat cardiomyocytes labeled with LacZ and green fluorescent protein (GFP) were c...

متن کامل

Electromechanical Coupling between Skeletal and Cardiac Muscle

Skeletal myoblasts form grafts of mature muscle in injured hearts, and these grafts contract when exogenously stimulated. It is not known, however, whether cardiac muscle can form electromechanical junctions with skeletal muscle and induce its synchronous contraction. Here, we report that undifferentiated rat skeletal myoblasts expressed N-cadherin and connexin43, major adhesion and gap junctio...

متن کامل

Perspectives: Cardiomyocytes from Skeletal Muscle Stem Cells for Cardiac Repair

Heart failure is a major contributor to mortality in the United States. Many cardiomyocytes (CM) die following myocardial insult, and the post-natal mammalian heart has very limited regenerative capacity. Heart organ transplantation is a final therapeutic option to prevent patient death when heart failure is imminent. However, donor organ availability cannot completely meet current demands, and...

متن کامل

Structural interaction between RYRs and DHPRs in calcium release units of cardiac and skeletal muscle cells.

Excitation-contraction (e-c) coupling in muscle cells is a mechanism that allows transduction of exterior-membrane depolarization in Ca2+ release from the Sarcoplasmic Reticulum (SR). The communication between external and internal membranes is possible thanks to the interaction between Dihydropyridine Receptors (DHPRs), voltage-gated Ca2+ channels located in exterior membranes, and Ryanodine R...

متن کامل

Isolation and optimization of mice skeletal muscle satellite cells using preplating method and culture media substitution

Introduction: Satellite cells are known as the main regenerative cell type in skeletal muscles. Our study established a modified digestion and preplating method for the isolation of slow or weak adherent cells for the enrichment of satellite cells. Low-survival rate of these primary stem cells prompted us to address whether cell culture medium substitution might change cell viability status. M...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Circulation Research

سال: 2004

ISSN: 0009-7330,1524-4571

DOI: 10.1161/01.res.0000125294.04612.81